Senescence of Timing Reverted: NAD+ Rejuvenates the Circadian Clock
نویسندگان
چکیده
منابع مشابه
The time of metabolism: NAD+, SIRT1, and the circadian clock.
The mammalian cell contains a molecular clock that contributes, within each organism, to circadian rhythms and variety of physiological and metabolic processes. The clock machinery is constituted by interwined transcriptional-translational feedback loops that, through the action of specific transcription factors, modulate the expression of clock-controlled genes. These oscillations in gene expr...
متن کاملIntact interval timing in circadian CLOCK mutants.
While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval-timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/- and -/- mutant male mice ...
متن کاملPerfect timing: epigenetic regulation of the circadian clock.
In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of the routes by which phenotype is shaped. Phenotypes that arise without a concomitant mutation of the underlying genome are termed epigenetic phen...
متن کاملTiming of the ovarian circadian clock is regulated by gonadotropins.
The timing of ovulation is critically important to the success of reproduction. Current thinking attributes the timing of ovulation to LH secretion by the pituitary, itself timed by signals from the hypothalamus. The discovery of an internal circadian timer in the ovary raises the possibility that ovulation is in fact timed by an interaction between clocks in the hypothalamus/pituitary and thos...
متن کاملCircadian clock determines the timing of rooster crowing
of a widespread species than to be faced with the challenge of conserving every population because all are distinctive. Undoubtedly, some reptile species have already gone extinct before we even knew they existed. But a lot remain to be discovered: for example, a single square kilometre of Australian desert can contain 14 co-existing species of the lizard genus Ctenotus (many of them so similar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2020
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2020.05.010